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Sigma Theta Tau International was founded in 1922 by six nursing students at the Indiana University Training School of Nurses, now the Indiana University School of Nursing in Indianapolis, Indiana. Mary Tolle, Edith Moore, Marie Hippensteel, Dorothy Garrigus, Elizabeth Russel, and Elizabeth McWilliams envisioned a Society that would recognize scholarship, stand for the best in nursing, encourage future leaders, and provide a social forum.
They believed that the Society would provide a way to advance the status of nursing as a profession. The founders chose the name from the initials of the Greek words "Storge", "Tharos", and "Tima" meaning "love", "honor", and "courage".