Introduction to Molecular Medicine is a two semester course for first year MD-PhD students taught by the Director of the MD-PhD Program, with other faculty from the basic science and clinical departments. Through lectures, small group discussion, evaluation of primary literature, and presentations/discussions with current KUMC faculty, students will be introduced to the process of investigating the molecular and cellular derangements that underlie human disease. Order of topics mirror, to some extent, the subjects of first-year modules. There will be particular emphasis on the diverse research methods and models systems used to investigate the molecular basis of disease and understanding how such investigations can be translated to answer clinically relevant questions. Students are evaluated by both group activity and individual preparation and participation. Prerequisites: Enrollment in the MD-PhD Program.
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The elective provides an overview of hospital-based pathology practice. It consists of a two-week rotation in the anatomic pathology core (surgical pathology, cytology and autopsy), a one-week rotation in hematopathology and a one-week rotation in microbiology/cytogenetics. Students in the anatomic pathology core will have the opportunity for supervised prosection of surgical specimens, participation in the "sign-out" of surgical and cytology samples with the attending staff, and participation in autopsy if available. Students in hematopathology will participate in the daily sign-out of bone marrow biopsy specimens. The focus in this segment of the rotation is on the diagnosis of blood and bone marrow disorders such as leukemia. The rotation in microbiology/cytogenetics will afford the student the opportunity to perform his/her own karyotype and learn about the diagnosis of infectious diseases by appropriate culture techniques. Students are active participants in their learning via required pre-test, post-test, assigned readings, and PowerPoint case presentation at the end of the rotation. Final grade is based on exam score (25%), case presentation (25%), and staff assessment of performance during the rotation (50%). Prerequisites: Completion of core clinical clerkships.
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This rotation affords the student the opportunity to spend four weeks focused on a particular subspecialty of pathology or a pathology-based research elective. The department has subspecialists in dermatopathology, neuropathology, renal pathology, breast and hepatic pathology. The rotation consists of daily interpretation of subspecialty biopsies, participation in subspecialty conferences, slide set study, and assigned readings. Students participate in their own learning by setting their rotation objectives with faculty at the start of their elective and following through with a schedule of clinical, laboratory and core lecture conferences. Students will need to obtain the appropriate staff members' permission for the rotation as follows: dermatopathology (Garth Fraga); neuropathology (Kathy Newell); renal pathology (Timothy Fields); breast pathology (Fang Fan); hepatic pathology (Maura O'Neil). Prerequisites: Completion of the core clinical clerkships and permission of the faculty.
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