Immunoprecipitation Buffer
(Cell Lysis Buffer 2)

1 x

Reagent Final Conc. Volume Mass
dH2O   400 ml  
Triton X-100 1 % 5 ml  
NaCl Stock, 5 M 150 mM 15 ml  
1 M Tris-HCl pH 7.4 10 mM 5 ml  
0.5 M EDTA pH 8.0 1 mM 1 ml  
EGTA (MW 380.4) 1 mM   0.19 g
PMSF 0.1 M stock (toxic) 0.2 mM 1 ml  
NP-40 0.5 % 2.5 ml  

If needed, add fresh sodium vanadate to final conc. of 0.2 mM (tyrosine phosphatase inhibitor).

2 x

Reagent Final Conc. Volume Mass
dH2O   400 ml  
Triton X-100 2 % 10 ml  
NaCl Stock, 5 M 300 mM 30 ml  
1 M Tris-HCl pH 7.4 20 mM 10 ml  
0.5 M EDTA pH 8.0 2 mM 2 ml  
EGTA (MW 380.4) 2 mM   0.38 g
PMSF 0.1 M stock (toxic) 0.4 mM 2 ml  
NP-40 1 % 5 ml  

Add dH2O to 500 ml. If needed, add fresh sodium vanadate to final conc. of 0.4 mM (tyrosine phosphatase inhibitor).

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