Contact Information:
Institute of Maternal-Fetal Biology
Division of Cancer & Developmental Biology
Department of Pathology and Laboratory Medicine
University of Kansas Medical Center
3901 Rainbow Boulevard
Kansas City, Kansas 66160
Office: Lied 1014
Phone: (913) 588-0341
Fax: (913) 588-0385
Email: jvivian@kumc.edu
Laboratory: Lied 1019
Ph.D., University of Texas-Houston, 1999
Postdoctoral, University of North Carolina at Chapel Hill, 2000-2004
Assistant Professor
Division of Cancer & Developmental Biology
Department of Pathology and Laboratory Medicine
University of Kansas Medical Center
Member, Institute of Maternal-Fetal Biology
Member, Kansas Masonic Cancer Research Institute
Cell-cell communication is critical for normal embryogenesis, giving rise to altered gene expression in target cells to affect their developmental and differentiative potential. Many of the signaling molecules and pathways present in the early embryo are also utilized in adult life and homeostasis. For example, several TGF-beta signaling components that are absolutely required for embryonic development are shown to be somatically altered in many adult tumors, including colorectal and hepatocellular carcinomas. Thus understanding the functions of these factors in embryogenesis, aided by the rapid and stereotypic development of the mouse embryo, will provide insight into the genetic processes of tumor progression. The Vivian laboratory is interested in understanding several embryonic signaling, including early patterning and vasculogenesis. We utilize the genetic manipulability of the mouse to understand the molecular mechanisms of embryonic development, including functions of the components of TGF-beta signaling. Our laboratory takes advantage of technical advances in homologous recombination and chemical mutagenesis to generate mutations in the mouse genome.
Vivian, J. L., Gan, L., Olson, E. N., and Klein, W. H. (1999). A Hypomorphic Myogenin Allele Reveals Distinct Myogenin Expression Levels Required for Viability, Skeletal Muscle Development, and Sternum Formation. Dev. Biol. 208, 44-55
Vivian, J. L., Olson, E. N., and Klein, W. H. (2000). Thoracic Skeletal Defects in Myogenin- and MRF4-Deficient Mice Correlate with Early Defects in Myotome and Intercostal Musculature. Dev. Biol. 224, 29-41
Vivian, J. L., Chen, Y., Yee, D., Schneider, E., and Magnuson, T. (2002). An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N-nitrosourea-mutagenized mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA, 99, 15542-15547
Chen, Y., Vivian, J. L., and Magnuson, T. (2003). Gene-based chemical mutagenesis in mouse embryonic stem cells. Methods Enzymol. 365, 406-415
Vivian, J. L., Chen, Y., and Magnuson, T. (2004). Gene-based screens of chemically mutagenized mouse embryonic stem cells. In: Handbook of Embryonic Stem Cells. Lanza, R. P., et al (Eds), Academic Press. In Press
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