Diane L. Persons, M.D.

Contact Information:
Division of Cancer & Developmental Biology
Department of Pathology and Laboratory Medicine
University of Kansas Medical Center
3901 Rainbow Boulevard
Kansas City, Kansas 66160

Office: 1213 KU Hospital
Phone: 913 588-1728
Fax: 913 588-1777
Email: dpersons@kumc.edu

Laboratory: Lied 1021
Phone: 913 588-7297

Training:

M.A., University of Kansas, Lawrence, 1978; M.D., University of Kansas Medical Center, 1987; Pathology Residency, University of Kansas Medical Center, 1987-1991; Research Fellowship, Mayo Graduate School, 1991-1993; Cytogenetics Fellowship, Mayo Graduate School of Medicine, 1993-1994.

Academic Position(s):

Associate Professor, Pathology and Laboratory Medicine, University of Kansas Medical Center

KUMC Center/Institute Affiliation(s):

Member, Kansas Masonic Cancer Research Institute

Research Interests:

Basic research projects include examination of signal transduction pathways involved in the cellular response to cisplatin, use of signal transduction inhibitors as enhancers of cisplatin cytotoxicity, and use of high-throughput screening for identifying small molecules that enhance the tumor cell killing effect of cisplatin. Clinical and translational research projects include examination of cytogenetic abnormalities as predictive or prognostic markers in leukemia, multiple myeloma, and solid tumors and development of molecular cytogenetic tests for use in clinical oncology.

Clinical Activities:

Director, Cytogenetics Laboratory, KUMC
Director, Pathology Residency Program, KUMC
Co-Chair, Cytogenetics Committee, Southwest Oncology Group
Member, Cytogenetics Resource Committee, College of American Pathologists/American College of Medical Genetics

Selected recent publications:

• DeHaan, R.D., Yazlovitskaya, and Persons, D.L. (2001) ERK modulation of expression of p53 regulated genes during cisplatin treatment. Cancer Chemotherapy and Pharmacology 48, 383-388
• Tubbs, R.R., Colley, L., Hsi, E.D., Linden, M.D., Pettigrew, N.M., Rickert, R.R., Said, J.W., Bayer-Garner, I.B., Nagle, R.B., Brothman, A.R., Persons, D.L., Habegger Vance, G., Mascarello, J.T., Roa, K.W., Herrmann, M., DeWald, G. and Park, J.P. (2002) Clinical laboratory assays for HER-2/neu amplification and overexpression: Quality assurance, standardization, and proficiency testing. Archives of Pathology and Laboratory Medicine 126, 803-808
• Slovak. M.L., Zhang, F., Tcheurekdjian, L., Bobadilla, D., Bedell, V., Arber, D.A., Persons, D.L., Sosman, J.A., Murata-Collins, J.L. (2002) Targeting multiple genetic aberrations in isolated tumor cells by Spectral Fluorescence In-Situ Hybridization (S-FISH). Cancer Detection and Prevention 26, 171-179
• Yazlovitskaya EM and Persons DL. (2003) Activation of ATR by cisplatin and affect on G2/M cell cycle components. Anticancer Research 23, 2275-2280
• Mascarello, J.T., Cooley, L.D., Dewald, G.W., Brothman, A.R., Herrman, M., Park, J.P., Persons, D.L., Rao, K.W., Schneider, N.R., Davison, K., and Vance, G.H. (2003) Problems with ISCN FISH nomenclature make it not practical for use in clinical test reports or cytogenetic databases. Genetics in Medicine 5, 370-37