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Pathology & Laboratory Medicine
School of Medicine  :  Pathology & Laboratory Medicine

Linheng Li Laboratory

Li Lab
Seated L to R: Xi (CiCi) He, Tong Yin, Jason Ross, Linheng Li
Standing L to R: Ryohichi Sugimura, Mark Hembree, Jun Park, John Perry, David Scoville,
Justin Grindley, Yucai Xie, Karen Tannen

Highlighted work from the lab

  1. Molecular basis of multipotentiality of stem cells.
  2. Identification of the hematopoietic stem cell niche.
  3. BMP and Wnt signaling Ying-Yang controls intestinal stem cell (ISC) properties.
  4. Molecular mechanism underlying conversion of normal stem cells to cancer stem cells.
  5. Discovery of two reserved and primed hematopoietic stem cell populations.

Future directions

  1. We extend our finding of HSC niche and attempt to further dissect the niche signals and to investigate how these signals coordinate to regulate stem cell self-renewal. We also attempt to systematically map out the different microenvironments required for different stages of hematopoietic lineage commitment and maturation.
  2. As cancer is derived from cancer stem cells, a key to completely cure cancer may depend on whether we can successfully target on cancer stem cells (not just the bulk of tumor mass). To this end, identification and characterization of cancer stem cells will be the essential step. We are engaged in identification of cancer stem cells in hematopoietic and intestinal tissues, following with characterization of cancer stem cells at cellular and molecular levels.

Li Lab Team Members

L Li

Linheng Li
Position: Investigator
Email:LIL@stowers-institute.org

X He

Xi He
Position: Senior Research Specialist
Email:CCH@stowers-institute.org

J Grindley

Justin Grindley
Position: Senior Research Associate
Email:JCG@stowers-institute.org

M Hembree

Mark Hembree
Position: Laboratory Manager I
Email:MJH@stowers-institute.org

J Perry

John Perry
Position: Postdoctoral  Research Fellow
Email:JMP@stowers-institute.org

T Yin

Tong Yin
Position: Postdoctoral Research Fellow
Email:TOY@stowers-institute.org

Y Xie Yucai Xie
Graduate Student
Position: Predoctoral Researcher
Email:YUX@stowers-institute.org
D Scoville

David Scoville
Graduate Student
Position: Predoctoral Researcher
Email:DHS@stowers-institute.org

J Ross

Jason Ross
Graduate Student
Position: Predoctoral Researcher
Email:JTR@stowers-institute.org

R Sugimura

Ryohichi Sugimura
Graduate Student
Position: Predoctoral Researcher
Email:rsu@stowers-institute.org
J Park

Jungeun Park
Position: Research Technician II
Email:jup@stowers-institute.org

Karen Tannen

Karen Tannen
Position: Senior Admin Assistant
Phone: 816-926-4083
Email:knt@stowers-institute.org

Contact Information

Linheng Li, Ph.D.
Investigator
Stowers Institute for Medical Research
1000 East 50th Street
Kansas City, MO 64110
Phone: 816-926-4081
Fax: 816-926-2025
E-mail:lil@stowers-institute.org