
Contact Information:
University of Kansas Medical Center
3901 Rainbow Boulevard
4030 Robinson
Mail Stop 1027
Kansas City KS 66160-7312
Office: 4030 Robinson
Phone: (913) 588-4700
Fax: (913) 588-4701
Email: rjensen@kumc.edu
Laboratory: Wahl Hall East 1002, 1003, 1004, 1005
Phone: (913) 588-0583
Doctoral Degree: M.D., Vanderbilt University, 1984
Residency Training: Anatomic Pathology, Vanderbilt University Hospital, 1984-1987
Postdoctoral Fellowship: American Cancer Society Clinical Oncology Fellow, 1987-1988
Postdoctoral Fellowship: National Institutes of Health, National Cancer Institute, Biotechnology Training Fellow, 1988-1991
Director, Kansas Masonic Cancer Research Institute
William R. Jewell, MD, Distinguished Kansas Masonic Professor
Professor, Division of Cancer & Developmental Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
Professor, Department of Anatomy & Cell Biology, University of Kansas Medical Center (joint appointment)
Director, University of Kansas Cancer Center
Director, Kansas Masonic Cancer Research Institute
Director, Laboratory of Cellular and Molecular Pathology
The Laboratory of Cellular and Molecular Pathology is interested in the characterization of premalignant and malignant breast lesions, particularly the earliest genetic alterations that result in breast neoplasia, and the transition from in situ disease to invasion. We are currently investigating these changes by proteomic-based discovery analysis via MALDI-TOF mass spectroscopy paired with Laser Capture Microdissection. The overall goal is to elucidate changes in proteomic expression between the epithelial and stromal components of normal, premalignant, and malignant breast tissue and to exploit these differences to develop novel agents that can serve as effective therapeutic or preventive treatments.
In addition, we are in the process of characterizing a series of wild type human and mutant BRCA1 constructs in transgenic mice. These mice appear to have a number of interesting phenotypes in regards to development, differentiation, and susceptibility to carcinogen challenge in comparison to wild-type controls. Future studies will examine the tumor susceptibility of mice crossbred with dominant transgenic oncogenes and the effect of gene dosage on phenotype.
Breast pathology with a special interest in premalignant and malignant breast disease.
