Sub-Specialty Training in OTOHNS
VII Research Experience
Research training is provided throughout the residency. Five-months
are dedicated to the research rotations in the PGY-3 and PGY-4
years. It is closely mentored by the Resident Research Committee,
chaired by the OTOHNS Director of Research, Dianne Durham, PhD.
In general the bulk of data collection is completed during the
course of the four-month protected research time, and additional
data analysis, preparation of presentations, and completion of
manuscripts are carried out subsequently. Research can be performed
in the Departmental Auditory and Vestibular Neuroscience Laboratory
headed by Dr. Durham or another laboratory at the KUMC or VAMC.
The main OTOHNS Research Laboratory is housed in the Ralph L.
Smith Mental Retardation Research Center (MRRC), located next to
the hospital. This laboratory was established by Dr. Durham to
investigate biochemical and anatomical changes in central auditory
neurons following manipulation of peripheral auditory input. Similar
studies are being performed in the vestibular system. The laboratory
houses equipment for preparing tissue samples for light or electron
microscopy, including a cryostat and paraffin microtome, as well
as several research quality microscopes. The OTOHNS Department
employs full-time technicians who oversee the day-to-day operation
of the research lab and are available for training in histological
techniques and a variety of tissue processing. Dr. Doug Girod's
laboratory provides a sound-proof booth including equipment for
controlled noise exposure of laboratory animals as well as measuring
auditory evoked potentials and otoacoustic emissions.
The KUMC Clinical Vestibular Laboratory houses a Neurokinetics
rotary chair, an Equitest posturography platform, and a Nicolet
Nystar ENG apparatus and other ancillary equipment for the analysis
of vestibular function in humans. A Nicolet Viking evoked potential
apparatus is used for various evoked potentials and intraoperative
monitoring of cranial nerve function. Ongoing studies include a
prospective investigation of inner ear function after ototoxic
drug exposure and intraoperative monitoring of endolymphatic sac
and inner ear function in Meniere’s disease.
Several institutional facilities supplement the resources outlined
above including a core facility for molecular biology, which contains
facilities for RNA and DNA analysis, PCR, in situ hybridization,
and gene chip microarray analysis, etc. An AAALAC-approved animal
facility, located in the MRRC, provides veterinary support and
housing for research animals. In addition, common use procedure
rooms for small animal surgery as well as a fully-equipped OR are
available within the main animal facility. An electron microscopy
research laboratory (EMRL) is maintained by the institution for
use by all KUMC investigators. The facility houses two transmission
and one scanning electron microscope and employs two technicians
to manage the facility and prepare tissue samples.
In addition to the basic science research projects outlined above,
residents also participate in more clinically oriented projects
in collaboration with the clinical OTOHNS faculty. These projects
are accomplished during clinical rotations and often involve chart
reviews, case reports, etc. These projects are also funded and
presented at both regional and national meetings.
The success of resident and faculty research, both clinical and
basic science, is showcased at the annual University of Kansas
Department of OTOHNS Alumni Day Research Conference held in June
of each year. This all-day forum includes research and clinical
presentations as well as discussions amongst clinical and research
faculty, residents, alumni, and community OTOHNS physicians as
well as an invited nationally-renowned OTOHNS guest. Each resident
is then encouraged and funded to also present their project at
a national meeting, such as the fall Academy of OTOHNS meeting
or the midwinter Association for Research in Otolaryngology meeting.
During their residency training, all OTOHNS residents are required
to publish at least one manuscript in a peer-reviewed journal.
Annual Alumni Day Golf Outing