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Otolaryngology - Head and Neck Surgery
School of Medicine  :  Otolaryngology - Head and Neck Surgery  :  Faculty and Staff

Dianne Durham, PhD


Dianne Durham, PhD

Associate Professor
Director, Division of Research
(913) 588-6731
ddurham@kumc.edu

Education and Training


BS: 1982, Purdue University, West Lafayette, Indiana.
PhD: 1986, Washington University, St. Louis, Missouri.
Post doctoral Fellow: University of Virginia Medical Center, Charlottesville, Virginia.
Research Interests: Effects of altered auditory and vestibular experience on the central nervous system, CNS neuronal cell death.

Publications

  • Smittkamp, S.E., Park, D.L., Girod, D.A. and Durham, D. Effects of age and cochlear damage on the metabolic activity of the avian cochlear nucleus. Hearing Research, 175:101-111, 2003.
  • Morgan, AS, Nuckols, D., Durham D. and Girod, DA, Anatomical and functional recovery of chicken cochlea following topic unilateral application of gentamicin. Hearing Research, Submitted 2003.
  • Tucci, D.L., Cant, N.B., and Durham, D. Conductive hearing loss results changes in cytochrome oxidase activity in gerbil central auditory system. J. Assoc. Res. Otolaryngol, 3:89-106, 2002.
  • Durham, D., Park, D.L. and Girod, D.A. Breed differences in cochlear integrity in adult, commercially raised chickens. Hearing Research, 166:82-95, 2002.
  • Park, D.L., Girod, D.A. and Durham, D. Avian brainstem neurogenesis is stimulated during cochlear hair cell regeneration. Brain Resesarch, 949:1-10, 2002.
  • Smittkamp, S.E., Colgan, A.L., Park, D.L., Girod, D.A., and Durham, D. Time course and quantification of changes in cochlear integrity observed in commercially-raised broiler chickens. Hearing Research, 170:139-154, 2002.
  • Bunting, E.C., Park, D.L. Durham, D. and Girod, D.A. Gentamicin pharmacokinetics in the chick cochlea. Laryngoscope, Submitted 2002.
  • Tucci, D.L., Cant, N.B., and Durham, D. Conductive hearing loss results changes in cytochrome oxidase activity in gerbil central auditory system. J. Assoc. Res. Otolaryngology, 3:89-106, 2002.
  • Tucci, D.L., Cant, N.B., and Durham, D. Effects of conductive hearing loss on gerbil central auditory system activity in silence. Hearing Research, 155:124-132, 2001.
  • Durham, D., Park, D.L., and Girod, D.A. Central nervous system plasticity during hair cell loss and regeneration. Hearing Research, 147:145-159, 2000.
  • Lurie, D.I. and Durham, D. Neuronal death, not axonal degeneration, results in significant gliosis within the cochlear nucleus of adult chickens. Hearing Research, 149:178-188, 2000.
  • Girod, D.A., Park, R.H., Park, D.L. and Durham,D. Morphological and functional changes in the avian cochlea after single high-dose gentamicin. Am. J. Otolaryngology, 21:379-388; 2000.
  • Edmonds, J., Hoover, L.A., and Durham, D. Breed differences in deafferentation-induced neuronal cell death and shrinkage in chick cochlear nucleus. Hearing Research, 127:62-76, 1999.
  • Tucci, D.L., Cant, N.B., and Durham, D. Conductive hearing loss results in a decrease in central auditory system activity in the young gerbil. Laryngoscope, 109:1359-1371, 1999
  • Park, D.L., Girod, D.A. and Durham, D. Tonotopic changes in 2-deoxyglucose activity in chick cochlear nucleus during hair cell loss and regeneration. Hearing Research, 138:45-55, 1999.
  • Husmann, K.R., Morgan, A.S., Girod, D.A., and Durham, D. Round window administration of gentamicin: A new method for the study of ototoxicity of cochlear hair cells. Hearing Research, 125:109-119, 1998.
  • Park, D.L., Girod, D.A., and Durham, D.: Evidence for loss and recovery of chick brainstem auditory neurons during gentamicin-induced cochlear damage and regeneration. Hearing Research, 126:84-98, 1998.
  • Hyde, G.E. and Durham, D.: Rapid increase in mitochondrial volume in nucleus magnocellularis neurons following cochlea removal. J. Comp. Neurol. 339:27-48, 1994.
  • Hyde, G.E. and D. Durham: Increased deafferentation-induced cell death in chick brainstem auditory neurons following blockade of mitochondrial protein synthesis with chloramphenicol. J. Neuroscience 14:291-300, 1994.
  • Durham, D., Matschinsky, F.M., and Rubel, E.W : Altered malate dehydrogenase activity in n. magnocellularis of the chicken following cochlea removal. Hearing Research, 70:151-159, 1993.
  • Born, D.E., Durham, D. and Rubel, E.W : Afferent influences on brainstem auditory nuclei in the chick: Nucleus magnocellularis neuronal activity following cochlea removal. Brain Research 557:37-47, 1991.
  • Rubel, E.W, Hyson, R.L. and Durham, D.: Afferent regulation of neurons in the brain stem auditory system. J. Neurobiol. 21:169-196, 1990.
  • Richardson, B.E. and Durham, D.: Blood flow changes in chicken brain stem auditory nuclei following cochlea removal. Hearing Research 46:53-62, 1990.
  • Hyde, G.E. and Durham, D.: Cytochrome oxidase response to cochlea removal in chicken auditory brainstem neurons. J. Comp. Neurol. 297:329-339, 1990.
  • Code, R.A., Durham, D. and Rubel, E.W : Effects of cochlea removal on GABAergic terminals in nucleus magnocellularis of the chicken. J. Comp. Neurol. 301:643-654, 1990.
  • Durham, D., Rubel, E.W and Steel, K.S.: Cochlear ablation in deafness mutant mice: 2-deoxyglucose analysis suggests no spontaneous activity of cochlear origin. Hearing Research 43:39-46, 1989.
  • Durham, D. and Rubel, E.W: Afferent influences on brain stem auditory nuclei of the chicken: Changes in succinate dehydrogenase activity following cochlea removal. J. Comp. Neurol. 231:446-456, 1985.
  • Durham, D. and Woolsey, T.A.: Functional organization in cortical barrels of normal and vibrissae-damaged mice: A (3H) 2-deoxyglucose study. J. Comp. Neurol. 235:97-110, 1985.
  • Simons, D.J., Durham, D., and Woolsey, T.A.: Functional organization of mouse and rat SmI barrel cortex following vibrissal damage on different postnatal days. Somatosens. Res. 1:207-245, 1984.
  • Durham, D. and Woolsey, T.A.: Effects of neonatal whisker lesions on mouse central trigeminal pathways. J. Comp. Neurol.223:424-447, 1984.
  • Rubel, E.W., Born, D.E., Deitch, J.S., and Durham, D.: Recent advances toward understanding auditory system development. In: Hearing Science. C.I. Berlin (Ed.) College Hill Press, San Diego, pp. 109-157, 1984.
  • Dietrich, W.D., Durham, D., Lowry, O.H., and Woolsey, T.A.: "Increased" sensory stimulation leads to changes in energy related enzymes in the brain. J. Neurosci. 2:1608-1613, 1982.
  • Durham, D., Woolsey, T.A., and Kruger, L.: Cellular localization of 2-[3H]deoxy-D-glucose from paraffin-embedded brains. J. Neurosci. 1:519-526, 1981.
  • Dietrich, W.D., Durham, D., Lowry, O.H., and Woolsey, T.A.: Quantitative histochemical effects of whisker damage on single identified cortical barrels in the adult mouse. J. Neurosci. 1:929-935, 1981.
  • Woolsey, T.A., Durham, D., Harris, R.M., Simons, D.J., and Valentino, K.L.: Somatosensory Development. In: Development of Perception. Psychobiological Perspectives. R.N. Aslin, J.R. Roberts and M.R. Peterson (Eds.) Academic Press, New York, pp. 259-292, 1981.
  • Durham, D. and Woolsey, T.A.: Acute whisker removal reduces neuronal activity in barrels of mouse SmI cortex. J. Comp. Neurol. 178:629-644, 1978.
  • Green, M.C., Durham, D., Mayer, T.C., and Hoppe, P.C.: Evidence from chimaeras for the pattern of proliferation of epidermis in the mouse. Genet. Res. (Camb.) 29:279-284, 1977.
  • Durham, D. and Woolsey, T.A.: Barrels and columnar cortical organization: Evidence from 2-deoxyglucose (2-DG) experiments. Brain Res. 137:169-174, 1977.