Stephen Lauer, Ph.D., M.D.

Clinical Interests

• Cardiovascular risk assessment
• Smoking cessation
• Asthma

Education & Training:

• Undergraduate: BA (Biochemistry): University of Kansas, Lawrence, KS;
• Postgraduate:
  • Ph.D. (Biochemistry): University of Texas, Austin, TX;
  • M.D.: University of California - Irvine;
• Residency: University of California- San Francisco

Professional Certification:

• American Board of Pediatrics
• NRP Provider
• PALS

Professional Societies:

• American Academy of Pediatrics (AAP)
• Kansas Chapter of AAP
• Physicians for a National Health Program

Honors and Awards:

• American Heart Association Grant-in-Aid, 1988-1991
  " Apolipoprotein E gene regulation in the developing macrophage."
• 1993 - 1994 - LCME Blue Ribbon Faculty Subcommittee
• 1994 - Grace B. Bell Prize for Achievement in Biological Chemistry
• 1994 - Family Medicine Department Summer Research Fellowship
• 1995 - 1997 - Peer Review Committee
• 1995 - 1997 - Student Member of Clerkship Coordinator Committee
• 1996 - 1997 - Chairperson of Peer Review Committee
• 1997 - Evangeline Percival Award for Excellence in Pediatrics
• 1997 - Election to AOA
• 2000 - Nesozzi Award, Pediatric Residency UCSF

Publications:

• Journals:
  • Lauer, S.J., Burks, E., Irving, J.D., and Ravel, J.M. (1984) "Purification and characterization of three elongation factors EF- 1(alpha), EF- 1(beta, gamma) and EF-2 from wheat germ."
    J. Biol. Chem. 259: 1644-1648.
  • Browning, K.S., Yan, T.F.J., Lauer, S.J., Aquino, L.A., Tao, M., and Ravel, J.M. (1985) "Phosphorylation of wheat germ initiation factors and ribosomal proteins."
    Plant Physiol. 77:370-373.
  • Lauer, S.J., Burks, E.A., and Ravel, J.M. (1985) "Characterization of initiation factor 3 from wheat germ. 1. Effects of proteolysis on activity and subunit composition."
    Biochemistry 24:2924-2928.
  • Lauer, S.J., Browning, K.S., and Ravel, J.M. (1985) "Characterization of initiation factor 3 from wheat germ. 2. Effects of polyclonal and monoclonal antibodies on activity."
    Biochemistry 24:2928-2931.
  • Lax, S.R., Lauer, S.J., Browning, K.S., and Ravel, J.M. (1986) "Isolation and characterization of initiation factors from wheat germ."
    Methods Enzyrnol. 118: 109-128.
  • Lauer, S.J., Walker, D., Elshourbagy, N.A., Reardon, C.A., Levy-Wilson, B., and Taylor, J.M. (1988) "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene."
    J. Biol. Chem. 263:7277-7286.
  • Wernette-Hamrnond, M.E., Lauer, S.J., Corsini, A,, Walker, D.,Taylor, J.M., and Rall, S.C., Jr. (1989) "Glycosylation of human apolipoprotein E: The carbohydrate attachment site is threonine 194."
    J. Biol. Chem. 264: 9094-9101.
  • Bostrom, K., Laner, S. J., Poksay, K., Garcia, Z., Taylor,J.M., and Innerarity, T.L. (1989) "Apolipoprotein B48 RNA editing in chimeric apolipoprotein EB mRNA."
    J. Biol. Chem. 264: 15701-15708.
  • Simonet, W.S., Bucay, N., Lauer, S.J., Wirak, D.O., Stevens, M.E., Weisgraber, K.H., Pitas, R.E., and Taylor, J.M. (1990) "In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice."
    J. Biol. Chem. 265: 10809-10812.
  • Taylor, J.M., Chang, D.J., Leren, T.P., Walker, D., and Lauer, S.J. (1990) "Regulatory elements of the apolipoprotein E gene."
    In: Atherosclerosis Reviews, Vol. 20, Biotechnology of Dyslipoproteinemias: Applications in Diagnosis and Control (Lenfant, C., Albertini, A., Paoletti, R., and Catapano, A.L., eds.). Raven Press, New York, pp. 47-53.
  • Taylor, J.M., Paik, Y.-K., Chang, D., Leren, T., Walker, D., and Lauer, S.J. (1990) "Regulatory elements of the apolipoprotein E gene."
    In: Drugs Affecting Lipid Metabolism - X (Gotto, A.M., and Smith, L.C., eds.).
    Elsevier Science Publishers, Amsterdam, pp. 165- 168.
  • Simonet, W.S., Bucay, N., Lauer, S.J., Pitas, R.E., Weisgraber, K.H., and Taylor J.M. (1990) "Independent regulatory elements control expression of the human apolipoprotein E gene in the liver and kidney of transgenic mice."
    In: Molecular Biology of Atherosclerosis (Proceedings of the 20 International Steenbock Symposium) Elsevier Science Publishing Co., Inc., New York. pp. 3-10.
  • Simonet, W.S., Bucay, N., Lauer, S.J., Pitas, R.E., Weisgraber, K.H., and Taylor J.M. (1990) "Downstream regulatory elements stimulate expression of the human aplipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice." Transaction of the Association of American Physicians CIII: 119-128.
  • Simonet, W. S., Bucay, N., Pitas, R.E., Lauer, S. J., and Taylor, J.M. (1991) "Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice."
    J. Biol. Chem. 266:8651-8654.
  • Taylor, J.M., Simonet, W.S., Bucay, N., Lauer, S.J., and de Silva, H.V. (1991) "Expression of the human apolipoprotein Wapolipoprotein C-I gene locus in transgenic mice."
    Curr. Opinion Lipidol. 2:73-80.
  • Davis, R.W., Pierotti, V.R., Hubl, S.T., Lauer, S.J., Witztum, J.L., McLean, J.W., and Young, S.G. (1991) "Lipoproteins in pinnepeds: Analysis of a high-molecular-weight form of apolipoprotein E."
    J. Lipid Res. 32:1013-1023.
  • Robinson, M.T., McCall, M.R., Rubin, E., Lauer, S.J., LaBelle, M., and Forte, T.M. (1992) "Apolipoprotein B genetic polyrnorphisms in several human hepatoma-derived liver cell lines."
    Biochem. Biophys. Res. Comm. 183 : 1224- 1229.
  • Jackson, S.M., Wood, L. C., Lauer, S., Taylor, J.M., Cooper, A. D., Elias, P. M., and Feingold, K.R. (1992) "Effect of cutaneous permeab~lityb arrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice."
    J. Lipid Res. 33: 1307-1314.
  • Simonet, W.S., Bucay, N., Lauer, S.J., and Taylor, J.M. (1993) "A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice"
    J. Biol. Chem. 268: 8221-8229
  • Yao., Z., Lauer, S. J., Sanan, D. A., and Fazio, S. (1993) "ApoA-IV is secreted on discrete HDL particles by the rat hepatoma cell line McAR-7777 transfected with apoA-IV cDNA"
    Arteriosclerosis 13 : 1476- 1486.
  • deSilva, H.V., Lauer, S. J., Wang, J., Simonet, W.S., Weisgraber, K.H., Mahley, R. W., and Taylor, J.M. (1994) "Overexpression of human apolipoprotoein C-111 in transgenic mice results in an accumulation of apolioprotein B48 remnants that is corrected by excess apolipoprotein E."
    J. Biol. Chem. 269: 2324-2335.
  • Ji, Z.-S., Lauer, S.J., Fazio, S., Bensadoun, A., Taylor, J.M., and Mahley, R.W. (1994) "Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture."
    J. Biol. Chem. 269: 13429-13436.
  • Fan, J.-L., Wang, J., Bensadoun, A., Lauer, S.J., Dang, Q., Mahley, R.W., and Taylor, J.M. (1994) "Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins."
    Proc. Natl. Acad. Sci. USA 91: 8724-8728.
• Books and Book Chapters:
• Swords, S., Lauer, S. J., and Nopper, A. J. Principles of Treatment in Pediatric Dermatology: Systemic Therapy in Pediatric Dermatology, 3rd edition Editors: Lawrence Schachner and Ronald Hansen, 2003
• Abstracts:
• Lauer, S.J., Burks, E., and Ravel, J.M. (1982) "Isolation of two forms of eIF-3 from wheat germ."
• Fed. Proc. 41:1041.
  Lauer, S.J. and Ravel, J.M. (1984) "Effects of monoclonal antibodies on the activity of eIF-3."
  Fed.Proc. 43 :2020.
• Paik, Y.-K., Lauer, S.J., Levy-Wilson, B., Elshourbagy, N.A., Mahley, R.W., Reardon, C.A., and Taylor, J.M. (1985) "Linkage of human apolipoprotein E and C-I genes, and expression of the apo-E promoter in cultured mammalian cells."
  Circulation 72311-142.
• Paik, Y.-K., Lauer, S.J., Chang, D., Reardon, C.A., Walker, D.W., Taxrnan, E., Mahley, R.W., Levy-Wilson, B., and Taylor, J.M. (1986) "Regulation of human apolipoprotein E and C-I gene expression."
  Circulation 74:II-284.
• Lauer, S.J., Walker, D., Levy-Wilson, B., and Taylor, J.M. (1987) "There are two copies of the human apolipoprotein C-I gene linked closely downstream fiom the apolipoprotein E gene."
  Fed. Proc. 46: 1948.
• Taylor, J.M., Lauer, S.J., Paik, Y.-K., Chang, D., Taxman, E., Mahley, R.W., Weisgraber, K.H., Lau, Y.-F., and Reardon, C.A. (1987) "Expression of the cloned apolipoprotein E gene after transfection into cultured cells."
  Fed. Proc. 46:2236.
• Fosslein, E., Weisgraber, K.H., Lauer, S.J., Boyles, J.K.,Taylor, J.M., Bollen, A.W., Pitas, R.E., and Mahley, R.W. (1988) "Apolipoprotein E and in vivo smooth muscle cell proliferation."
  Ann. Clin. Lab. Sci. 18:402.
• Bostrom, K., Lauer, S.J., Garcia, Z., Poksay, K.S., Taylor, J.M., and Innerarity, T.L. (1989) "Apolipoprotein B48 rnRNA editing of chimeric apolipoprotein EB mRNA."
  RNA Processing, Cold Spring Harbor Laboratories, Cold Spring Harbor, New York.
• Simonet, W.S., Bucay, N., Lauer, S.J., Wirak, D., Stevens, M., Weisgraber, K.H., Pitas, R.E., Mahley, R.W., and Taylor, J.M. (1990) "In transgenic mice, distinct 5' and 3' regulatory elements of the human apolipoprotein E gene determine mutually exclusive high liver or abnormally high kidney expression."
  Clin. Res. 38:360A.
• Simonet, W.S., Bucay, N., Lauer, S.J., de Silva, H.V., Pitas, R.E., Weisgraber, K.H., and Taylor, J.M. (1990) "Multiple tissue-specific regulatory elements control the expression of the human apolipoprotein E gene in
  transgenic mice."
  Arteriosclerosis 10: 773A.
• Lauer, S.J., Simonet, W.S., Bucay, N., de Silva, H.V., and Taylor, J.M. (1991) "Tissue-specific expression of the human apolipoprotein A-IV gene in transgenic mice."
  Arteriosclerosis 11 : 1390a.
• de Silva, H.V., Lauer, S.J., Simonet, W.S., Mas-Oliva, J., Weisgraber, K.H., and Taylor, J.M. (1991) "Overexpression of human apolipoprotein C-Ill in transgenic mice causes abnormal accumulation of low density pre-beta-migrating apolipoprotein B48-E-AT-containing and alpha-migrating apolipoprotein E-AI-containing lipoproteins."
  Arteriosclerosis 11 : 1391a.
• Ramos, T.K., Lauer, S.J., Goldstone, J., and Taylor, J.M. (1992) "Retroviral gene transfer of human macrophage colony stimulating factor into rabbit vascular smooth muscle cells results in expression in vitro."
  Circulation 86:I-472.
• deSilva, H.V., Lauer, S.J., Wang, J., Mahley, R.W., and Taylor, J.M. (1992) "Opposing effects of apolipoprotein E and C-III on lipoprotein remnant clearance."
  Circulation 86:I-471.
• Lauer, S.J., Ji, J., Fazio, S., Bensadoun, A., Taylor, J.M., and Mahley, R.W. (1993) "Human hepatic lipase secretion by transfected McA-RH7777 cells results in enhanced binding and clearance of remnant lipoproteins."
  Circulation 88: I-321.