Overview of the PKD Kidney Research Retrieval Program:

The PKD Tissue Repository and Biomaterials Core is supported by the National Institutes of Health to generate unique human reagents for PKD investigators, including primary cells isolated from cysts of discarded PKD kidneys. Studies using human ADPKD cells have allowed scientists to understand many of the cellular mechanisms responsible for cyst progression.

 

Information for the patient:

Why donate tissue for research?

Discarded PKD kidneys, removed during a nephrectomy (surgical removal of the non-functioning kidney), have great scientific value by allowing investigators  to study human cells that have genetic mutations responsible for the cyst formation.

Is the donation anonymous?

Yes.  All patient identifies are removed at the hospital prior to shipping the tissue(s).  Patient information is protected by HIPPA regulations.

How can I donate my discarded kidney to research?

PKD kidneys are donated by participating hospitals at the request and consent of the patient prior to the nephrectomy.   The PKD Foundation facilitates the retrieval of discarded kidneys and helps to coordinate the donation between the patient and the PKD Tissue Repository and Biomaterial Core at the Kansas University Medical Center.

 

Need more information?

If you are interested in participating in the PKD Kidney Research Retrieval Program or would like more information, please contact the PKD Foundation or the PKD Tissue Repository and Biomaterial Core Facility at the University of Kansas Medical Center (913-588-3811).

 

Information for the scientist:

What biomaterials are distributed to PKD scientists?

The following biomaterials may be available to the investigator depending on availability, approval by the Director and completion of material transfer agreements.

•   Fixed cystic tissue

•   Fresh frozen tissue

•   DNA

•   RNA

•   Primary cells

•   Immortalized cells

•   Cyst fluid

 

 

End-stage ADPKD kidney:

 

 

Monolayer of primary cells cultured from the cysts of an ADPKD kidney: