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School of Medicine  :  Internal Medicine  :  Research Overview

Clinical Trials

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Allergy, Immunology, & Rheumatology 
Condition Title Phase Status Principal Investigator Contact Info
Ankylosing Spondilitis A randomized double blind placebo controlled dose ranging study to evaluate the efficacy and safety of SAR153191 in patients with Ankylosing Spondylitis (AS) II Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Ankylosing Spondilitis A multicenter uncontrolled extension study evaluating the long term safety and efficacy of SAR153191 in patients with Ankylosing Spondylitis (AS) II Active/Not Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Bursitis Efficacy of Celebrex combined with lidocaine or lidocaine plus corticosteroid in the treatment of acute or recurrent bursitis at the shoulder or hip.      I Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Osteoarthritis Effect of Intra articular steroids on bone turn over in Osteoarthritis      I Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Osteoarthritis Single Center, randomized, double-blind, placebo-controlled treatment of Knee Osteoarthritis with Intraarticular infliximab. I Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A randomized, double-blind, placebo-controlled, dose ranging study with an active comparator to evaluate the efficacy and safety of CDP6038 administered subcutaneously for 12 weeks to subjects with active rheumatoid arthritis having previously failed TNF blocker therapy      II Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Phase 4, Multicenter, Randomized, 52-Week Study to Evaluate the Routine Assessment of Patient Index Data (RAPID3) Compared to the Clinical Disease Activity Index (CDAI) to Prospectively Predict Treatment Success at 52 Weeks Based on a Treatment Decision at Week 12 in Subjects with Moderate to Severe Rheumatoid Arthritis Receiving Certolizumab Pegol (CZP) IV Terminated Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Phase III, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of Two Dosing Regimens of Fostamatinib Disodium in Rheumatoid Arthritis Patients with an Inadequate Response to DMARDs III Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared with Adalimumab Monotherapy in Patients with Active Rheumatoid Arthritis   II Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of LY2127399 in Patients with Moderate to Severe Rheumatoid Arthritis (RA) who had an Inadequate Response to one or more TNF-α Inhibitors   III Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Golimumab Phase 3b, Multicenter, Switch Assessment of Subcutaneous and Intravenous Efficacy in Rheumatoid Arthritis Patients Who Have Inadequate Disease Control Despite Treatment with Etanercept (ENBREL®) or Adalimumab (HUMIRA®) III Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A phase 2, multi-center, open-label, follow up study to assess the long-term safety and efficacy of CDP6038 administered subcutaneously to subjects with active rheumatoid arthritis who completed study RA0056      II Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A Phase 3b, Multicenter, Open-Label Study to Evaluate the Long-Term Safety and Efficacy of LY2127399 in Patients with Rheumatoid Arthritis (RA) III Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis                      (OSKIRA-X): A Long-term Extension Study to Assess the Safety                     and Efficacy of Fostamatinib Disodium (FosD) in the Treatment of                   Rheumatoid Arthritis      II-III Recruiting Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP, INTERNATIONAL STUDY TO EVALUATE THE SAFETY AND EFFICACY OF OCRELIZUMAB COMPARED TO PLACEBO IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CONTINUING METHOTREXATE TREATMENT      III Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP, INTERNATIONAL STUDY TO EVALUATE THE SAFETY AND EFFICACY OF OCRELIZUMAB COMPARED TO PLACEBO IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS WHO HAVE AN INADEQUATE RESPONSE TO AT LEAST ONE ANTI-TNF-α THERAPY III Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
Rheumatoid Arthritis A PHASE II, RANDOMIZED, DOUBLE-BLIND, PARALLEL‑GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF OCRELIZUMAB IN COMBINATION WITH METHOTREXATE COMPARED WITH INFLIXIMAB PLUS METHOTREXATE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CURRENTLY RESPONDING INADEQUATELY TO ETANERCEPT OR ADALIMUMAB II Completed Herbert Lindsley, MD gdreiseszun@kumc
or 913-588-0681
SLE A Phase 3, Multicenter, Randomized, Double-Blind, Placebo controlled study to evaluate the Efficacy and Safety of Sucutaneous LY2127399 in Patients with Systemic Lupus Erythematous (SLE) (ILLUMINATE-1) III Recruiting Kevin Latinis, MD Sheryl Martin at smartin3@kumc.edu or 913-588-4020

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Cardiovascular Diseases 
Condition Title Phase Status Principal Investigator Contact Info
Ablation mapping Study of non contact mapping of AVNRT and characterization of slow and fast pathways using non-contact array mapping N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
ACS A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Risk Subjects Presenting with Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial - IMPROVE IT) IV Active/Not Recruiting Steven Owens, MD cmurray@mac.md
ACS comparison of outcomes with concomitant clopidogrel and proton pump inhibitors or histamie type-2 receptor antagonists therapy following ACS N/A Active/Not Recruiting Buddhadeb Dawn, MD vjeevanantham@kumc.edu
ACS The TRANSLATE-ACS Study: TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome N/A Recruiting Peter Tadros, MD cmurray@mac.md
Aortic Dissection Evaluation of the GORE Conformable TAG Thoracic Endoprosthesis for Treatment of Acute Complicated Type B Aortic Dissection IV Recruiting George "Trip" Zorn, MD spage3@kumc.edu
Aortic Valve Replacement Post Approval Clinical Study for the Medtronic 3f® Aortic Bioprosthesis Model 1000 IV Recruiting George "Trip" Zorn, MD spage3@kumc.edu
Aortic Valve Replacement Medtronic CoreValve US Pivotal Trial N/A Recruiting George "Trip" Zorn, MD spage3@kumc.edu
Atrial Fibrillation Use of Oral Steroids before Circumferential Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation to Improve Outcomes. N/A Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Atrial Fibrillation Impact of Atrial Fibrillation Ablation on Vagal Innervation and Gastric Motility:  Correlation to Esophageal Temperatures N/A Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Atrial Fibrillation IRrigated Ablation System Evaluation for AF  (IRASE AF) III Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Atrial Fibrillation Assessment of pulmonary vein antral isolation outcomes based on patients' CHADS2 score N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD mbiria@kumc.edu
Atrial Fibrillation Review of pulmonary vein antral isolation outcomes in patients with renal dysfunction N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD mbiria@kumc.edu
Atrial Fibrillation Predictors of recurrence of AF following ablation - the role of pericardial fat N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD jpillarisetti@kumc.edu
Atrial Fibrillation THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation  III Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Atrial Fibrillation Study of incidence and predictors of post-operative atrial fibrillation (POAF) after esophageal surgery N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Atrial Fibrillation Study of the feasibility of pulmonary vein antral isolation in patients with pneumonectomy N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Atrial Fibrillation Study of dabigatran versus warfarin in patients undergoing radiofrequency ablation for the treatment of atrial fibrillation N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Cardiac arrhythmias Study of the incidence of arrhythmias in patients with pulmonary hypertension N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Cardiac Resynchronization Therapy Cardiac Resynchronization Therapy in patients with Chronic Kidney Disease N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD vjeevanantham@kumc.edu
Cardiac Resynchronization Therapy Evaluation of radiofrequency ablation of premature ventricular ectopy in non-responders of cardiac resynchronization therapy N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD mbiria@kumc.edu
Cardiac Resynchronization Therapy Correlation between epicardial LV pacing lead location and CRT response N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Cardiac Rhythm Management Devices St. Jude Medical Product  Longevity and Performance (Score) Registry IV Recruiting Loren Berenbom, MD jkarson@mac.md
Cardiac Rhythm Management Devices Product Performance Platform: Medtronic Post-Approval Registry of Cardiac Rhythm Management Devices IV Recruiting Dhanunjaya Lakkireddy, MD jkarson@mac.md
Cardiac Rhythm Management Devices Study of the amount of force required to directly insert a device into subcutaneous tissue N/A Recruiting Rhea Pimentel, MD datkins@mac.md
Cardiovascular risk reduction Study of the effect of cardiac rehab-like program on patients with risk factors but no prior MI/revasc N/A Recruiting Brian Weiford, MD elarson@kumc.edu
Carotid Artery Stenosis Carotid Stenting for High Surgical Risk Patients Evaluating outcomes Through the collection of Clinical Evidence - CHOICE Registry IV Recruiting Kamal Gupta, MD sshea@mac.md
CHF Left Atrial Pressure Monitoring to Optimize Heart Failure (LAPTOP-HF) III Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Diagnostic angiography Correlation of coronary anatomic variants with false positive myocardial perfusion imaging N/A Active/Not Recruiting Mark Wiley, MD bchehab@kumc.edu
Elective PCI A Clinical Evaluation of the XIENCE™ V Everolimus Eluting Coronary Stent System (EECSS) in the Treatment of Subjects with de novo Native Coronary Artery Lesions III Active/Not Recruiting Mark Wiley, MD sshea@mac.md
Elective PCI XIENCE V Everolimus Eluting Coronary Stent System (EECSS) USA Post-Approval Study IV Active/Not Recruiting Mark Wiley, MD sshea@mac.md
Elective PCI SPIRIT PRIME Clinical Trial: A Clinical Evaluation of the XIENCE PRIME ™ and XIENCE PRIME ™ LL Everolimus Eluting Coronary Stent System III Active/Not Recruiting Mark Wiley, MD sshea@mac.md
Elective PCI Review of incidence of cardiac arrhythmia in patients undergoing cardiac catheterization and/or intervention N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD mbiria@kumc.edu
Hospital readmission Development of a model for predictors of readmission and interventions to decrease readmission rate N/A Active/Not Recruiting Buddhadeb Dawn, MD vjeevanantham@kumc.edu
ICD Implant SJ4 Post Approval Study IV Active/Not Recruiting Loren Berenbom, MD jkarson@mac.md
ICD Implant Tilt & Tune Study: comparison of 50/50% tilt vs tuned defibrillation waveforms for defibrillation threshold testing in right-sided ICD implants N/A Recruiting Rhea Pimentel, MD cmurray@mac.md
ICD Implant Post-approval study of the QuickFlex® model 1258T left heart pacing lead IV Recruiting Raghuveer Dendi, MD jkarson@mac.md
ICD Implant post approval study of MRI-compatible ICD system IV Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Lead Extraction Starfix Lead Extraction: registry of Attain 4195 lead extractions and extraction of other Medtronic FDA-approved leads IV Recruiting Loren Berenbom, MD jkarson@mac.md
Pacemaker / ICD generator change Impact of Pocket Revision on the Rate of Infection and Other Complications in Patients Requiring Pocket Manipulation for Generator Replacement and/or Lead Replacement or Revision: A Prospective,  Randomized, Single Blind Study N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD datkins@mac.md
Patent Foramen Ovale RESPECT Trial Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment III Recruiting Peter Tadros, MD sshea@mac.md
Peri-operative risk assessment Peri-operative risk assessment and cardiac events in patients undergoing bariatric surgery N/A Active/Not Recruiting Steven Freeman, DO ddomanski@kumc.edu
Postpartum Cardiomyopathy Postpartum Cardiomyopathy Prognosis With ICD Use N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD jpillarisetti@kumc.edu
SCD PRE-DETERMINE: Biological Markers and Sudden Cardiac Death Cohort  N/A Recruiting Steven Owens, MD sshea@mac.md
STEMI Comparison of gender differences/characteristics associated with adverse in-hosptial and long-term outcomes in STEMI N/A Active/Not Recruiting Buddhadeb Dawn, MD mgood@kumc.edu
Superficial Femoral Artery Stenosis The US Study for Evaluating Endovascular Treatments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By using the Protégé EverFlex Nitinol Stent System II III Active/Not Recruiting Peter Tadros, MD sshea@mac.md
Superficial Femoral Artery Stenosis CONTINuous Infra-Inguinal Stenting Using the Bard® LifeStent® VascUlar Stent SysteMs (CONTINUUM) III Recruiting Kamal Gupta, MD sshea@mac.md
Syncope Assessment of premature ventricular contractions in patients undergoing tilt table tests N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Thoracic aortic aneurysms Evaluation of the GORE TAG Thoracic Endoprosthesis Used in the Primary Treatment of Descending Thoracic Aneurysms (TAG 05-02) IV Active/Not Recruiting George "Trip" Zorn, MD cmurray@mac.md
Ventricular tachycardia Evaluation of predictors of outcomes in subjects who have had radiofrequency ablation of ventricular tachycardia N/A Active/Not Recruiting Dhanunjaya Lakkireddy, MD hboolani@kumc.edu
Women's heart health Study of the long-term impact of the Change of Heart Program on women's health N/A Recruiting Ashley Simmons, MD kdalton@mac.md
Women's heart health Prevention of cardiovascular disease in women through an OB/GYN and cardiology collaboration N/A Recruiting Ashley Simmons, MD asimmons2@mac.md

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Clinical Pharmacology 

Condition

Title

Phase

Status

Principal Investigator

Contact Info

Hyperlipidemia

A Multi-Center, Double-Blind, Placebo controlled, Parallel Group Study of Lipid Lowering Effects of XZK with patients with Hyperlipidemia

II

Recruiting

Patrick M. Moriarty, MD

bnolte@kumc.edu or
913-588-0734

Hypercholesterolemia

A Study comparing the effects of Pitavastatin, Atorvastatin, and Rosuvastatin  on plasma levels of CoQ10 (SPARQ)

NA

Recruiting

Patrick M. Moriarty, MD

bnolte@kumc.edu or
913-588-9734

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Endocrinology, Metabolism & Genetics 
Condition Title Phase Status Principal Investigator Contact Info
Osteoporosis, Lactation, DHA Effect of DHA Supplementation on Bone Density Changes in Lactating Women N/A Recruiting Leigh Eck, MD leck2@kumc.edu
or913-588-6022
Osteoporosis, Lactation, Vitamin D Impact of Vitamin D Supplementation on Lactation Associated Bone Loss N/A Active/Not Recruiting Leigh Eck, MD leck2@kumc.edu
or 913-588-6022

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Gastroenterology & Hepatology 
Condition Title Phase Status Principal Investigator Contact Info
Ascities TIPS  N/A Recruiting Johnson, Philip, MD 913-588-1822
CHB/Hep B Gilead GS-US 174-0149 A Phase 4, Randomized, Open-label, Active-Controlled, Superiority Study to Evaluate the Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) in Combination with Peginterferon α-2a (Pegasys®) versus Standard of Care Tenofovir Disoproxil Fumarate Monotherapy or Peginterferon α-2a Monotherapy for 48 Weeks in, Non-Cirrhotic Subjects with HBeAg-Positive or HBeAg-Negative Chronic Hepatitis B (CHB) IV Recruiting Taylor, Ryan, MD rtaylor@kumc.edu
Diabetic gastropareis A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Evaluation of the Efficacy and Safety of Once-Daily Administrations of TZP-102 for the Treatment of Symptoms Associated with Diabetic Gastroparesis II-III Recruiting Tuba Esfandyati, MD, MSc smartin3@kumc.edu
913-588-4020
Fecal incontinence Interstim Sacral Nerve Stimulation Therapy for Bowel Control: Fecal Incontinence Study. IV Active/Not Recruiting Tuba Esfandyati, MD, MSc elower@kumc.ed
913-588-3936
Gastroparesis Humanitarian Use Device Protocol for Enterra Therapy: Gastric Electrical Stimulation to Treat Nausea and Vomiting Associated with Gastroparesis. IV Active/Not Recruiting Tuba Esfandyati, MD, MSc elower@kumc.edu
913-588-3936
Gastroparesis and constipation A pilot, randomized, double-blind, placebo-controlled, parallel-group study to evaluate gastric emptying rate in patients with symptomatic gastroparesis and slow-transit constipation in response to FDA approved over-the-counter drug, GSP I Recruiting Tuba Esfandyati, MD, MSc smartin3@kumc.edu 913-588-4020
HCC/ Hepato cellular carcinoma SEARCH III Active/Not Recruiting Taylor, Ryan, MD rtaylor@kumc.edu
HCC/ Hepato cellular carcinoma Gideon HCC N/A Active/Not Recruiting Taylor, Ryan, MD rtaylor@kumc.edu
HCC/ Hepato cellular carcinoma The Role of Circulating Circulation Cancer Progenitor Cells in Recurrence of Hepatocellular Carcinoma After Liver Transplantation. N/A Recruiting Weinman, Steven, MD, PhD sweinman@kumc.edu
HCC/ Hepato cellular carcinoma, HCV/Hep C Mechanisms of Liver Injury by Hepatitis C and Alcohol. N/A Recruiting Weinman, Steven, MD, PhD sweinman@kumc.edu
HCV/ Hep C CONATUS II Terminated Gilroy, Richard, MD rgilroy@kumc.edu
HCV/ Hep C A randomized, Double –blinded, Multicenter Study to Evaluate the Efficacy and Safety of the HCV Polymerase Inhitor Prodrug (RO5024048) in Combination with Pegasys and Copegus for 24 weeks versus the Currently Approved Combination of Pegasys and Copegus in Treatment-Naïve Patients with Chronic Hepatitis C Genotype 1 or 4 Virus Infection II Active/Not Recruiting Taylor, Ryan, MD rtaylor@kumc.edu
HCV/ Hep C Prospective observational study on predictors of early on-treatment  response and sustained virological response in a cohort of treatment naïve HCV-infected patients treated with pegylated interferons N/A Completed Taylor, Ryan rtaylor@kumc.edu
Hepatic Encephalopathy A Phase 2 Randomized, Double-Blind, Placebo-Controlled Studyof the Safety and Efficacy aof HPN-100 for Maintaing Remission in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy ( HALT_HE) II Active/Not Recruiting Weinman, Steven, MD, PhD sweinman@kumc.edu
Irritable bowel syndrome (diarrhea) A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study of Asimadoline in  Diarrhea-Predominant Irritable Bowel Syndrome II-III Recruiting Tuba Esfandyati, MD, MSc elower@kumc.edu
or 913-588-3936
Opioid-induced Constipation An Open-Label 52-week Study to Assess the Long-Term Safety of NKTR-118 in Opioid-Induced Constipation (OIC) in patients with Non-Cancer-Related Pain IV Active/Not Recruiting Tuba Esfandyati, MD, MSc elower@kumc.edu
or 913-588-3936
Ulcerative Colitis and Chron's Disease The long-term Safety and Efficacy of MLN0002 in Patients with Ulcerative colitis and Crohn's Disease III Active/Not Recruiting Grisilano, Scott, MD sgrisolano@kumc.edu

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Infectious Disease 
Condition Title Phase Status Principal Investigator Contact Info
BK Virus Use of Cidofovir in the Treatment of BK Virus Infection in Patients Undergoing Allogenic Stem Cell Transplantation N/A Active/Not Recruiting Nita Ganguly, MD Lisa Clough, MD smccrea-robertson@kumc.edu
Candidiasis A Retrospective Review of a Comprehensive Cohort of Candidal Septic Shock: Impact of Antifungal Therapy on Outcome N/A Active/Not Recruiting Lisa Clough, MD Jessica Newman, DO smccrea-robertson@kumc.edu
Candidiasis A Retrospective Review of the Incidence of Ocular Candidiasis in Candida Bloodstream Infection. N/A Active/Not Recruiting Albert Eid, MD smccrea-robertson@kumc.edu
Candidiasis A Retrospective Review of Candida Bloodstream Infection in a Tertiary Medical Center.  Time to Initiation of Appropriate Antifungal Therapy and its Association with Outcome. N/A Completed Lisa Clough, MD smccrea-robertson@kumc.edu
Clostridium difficile Infection  Clostridium Difficile Toxoid Vaccine: A Phase II Randomized, Placebo-Controlled, Double-blind, Dose Ranging Study to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid Vaccine in Subjects with Clostridium Difficile Infection (CDI). II Active/Not Recruiting Lisa Clough, MD smccrea-robertson@kumc.edu
Device Development Development of Medication Delivery Device N/A Active/Not Recruiting Stephen Waller, MD smccrea-robertson@kumc.edu
Device Development Development of Device Removal System I Active/Not Recruiting Stephen Waller, MD smccrea-robertson@kumc.edu
Epstein Barr Virus Pre-emptive Treatment with Rituximab for Epstein-Barr Virus Reactivation after Allogenic Hematopoietic Stem Cell Transplantation:  A Safety and Efficacy Study N/A Completed Nita Ganguly, MD Lisa Clough, MD smccrea-robertson@kumc.edu
Hardware Infections Yield of Sonicated Cultures in Diagnosing Orthopaedic Hardware Infection. N/A Active/Not Recruiting El Atrouni, MD Samina Khumri, MD smccrea-robertson@kumc.edu
Herpes Simplex Encephalitis A Phase III Double-Blind, Placebo-Controlled Trial Of Long Term Therapy Of Herpes Simplex Encephalitis (HSE) : An Evaluation Of Valacyclovir. III Active/Not Recruiting Lisa Clough, MD smccrea-robertson@kumc.edu
Histoplasmosis Blastomycosis Evaluation of Antigen Detection for Diagnosis of Histoplasmosis and Blastomycosis N/A Active/Not Recruiting Kassem Hammoud, MD smccrea-robertson@kumc.edu
Infections Exploring the Use of a Novel Device for Reducing Catheter-related Bloodstream Infections. I Active/Not Recruiting Stephen Waller, MD smccrea-robertson@kumc.edu
Infections A Comparative Study of Incidence and Spectrum of Infections in Patients with Chronic Graft Versus Host Disease (GVHD) before, during, and after Extracorporeal Photopheresis (ECP). N/A Completed Nita Ganguly, MD Lisa Clough, MD smccrea-robertson@kumc.edu
Infective Endocarditis A Validation of Prediction Model for Cardiovascular Implantable Electronic Device-Related Infections and Infective Endocarditis N/A Active/Not Recruiting El Atrouni, MD Jenna Chaung, MD smccrea-robertson@kumc.edu
Influenza An Observational Study of the Clinical and Virologic Manifestations of Novel and Seasonal Influenza N/A Active/Not Recruiting Lisa Clough, MD smccrea-robertson@kumc.edu
Influenza Immune Response after Monovalent Influenza A (H1N1) 2009 Vaccine in Hemodialysis Patients N/A Active/Not Recruiting Lisa Clough, MD smccrea-robertson@kumc.edu
Liver Transplant Clinical and Laboratory Features Predicting Abdominal Abscess in Patients with Post-Liver (OLT) Transplant Fluid Collections  N/A Completed Stephen Waller, MD smccrea-robertson@kumc.edu
Tuberculosis Routine Use of a Whole Blood Interferon-γ Assay for the Diagnosis of Mycobacterium Tuberculosis at a Tertiary-Care University-Affiliated Hospital. N/A Completed Kassem Hammoud, MD smccrea-robertson@kumc.edu

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Nephrology & Hypertension 
Condition Title Phase Status Principal Investigator Contact Info
Autosomal Polycystic Kidney Disease Consortium for Radiologic imaging studies of polycistic kidney disease CRISP 3 N/A Active/Not Recruiting Grantham, Jared Cathy Creed RN, 588-0053
ccreed@kumc.edu
Autosomal Polycystic Kidney Disease Identifying Genetic Modifiers in ADPKD N/A Recruiting Grantham, Jared Cathy Creed RN, 588-0053
ccreed@kumc.edu
Autosomal Polycystic Kidney Disease Multi-center, Open-label, Extension Study to Evaluate the Long-term Efficacy and Safety of Oral Tolvaptan Tablet Regimens in Subjects with Autosomal Dominant Polycystic Kidney Disease (ADPKD) III Active/Not Recruiting Wang, Connie Sheri Copeland RN, 588-7691 scopeland2@kumc.edu
Autosomal Polycystic Kidney Disease A phase 3, multi-center, double-blind placebo-controlled, parallel-arm trial to determine long term safety and efficacy of oral tolvaptan regimens in adult subjects with autosomal dominant polycystic kidney disease III Active/Not Recruiting Winklhofer, Franz Sheri Copeland RN, 588-7691 scopeland2@kumc.edu
Autosomal Polycystic Kidney Disease A Multi-center, Longitudinal, Observational Study of Patients with Autosomal Dominant Polycystic Kidney Disease N/A Recruiting Wang, Connie Sheri Copeland RN, 588-7691 scopeland2@kumc.edu
Autosomal Polycystic Kidney Disease High Resolution MRI in Polycystic Kidney Disease: Implications for Prognosis N/A Recruiting Wang, Connie Cathy Creed RN, 588-0053
ccreed@kumc.edu
Autosomal Polycystic Kidney Disease Halt progression of polycystic kidney disease: efficacy of renin-angiotensin-aldosterone axis blockade in preventing/slowing renal function decline in ADPKD IV Active/Not Recruiting Winklhofer, Franz Pam Lanza RN, 588-8983  planza@kumc.edu
Chronic Kidney Disease (CKD) stage 3/4 Impact of vitamin D therapies on monocyte function in chronic kidney disease III Recruiting Stubbs, Jason Cathy Creed RN, 588-0053
ccreed@kumc.edu
Chronid Kidney Disease Differential Effects of Ergocalciferol and Cholecalciferol Therapies in Chronic Kidney Disease III Recruiting Stubbs, Jason Cathy Creed RN, 588-0053
ccreed@kumc.edu
End Stage Renal Disease - hemodialysis Dialysis outcomes and practice patterns study, DOPPS 4 N/A Recruiting McCarthy, Ellen Denise Loftiss RN, 588-7609  dloftiss@kumc.edu
End Stage Renal Disease - hemodialysis Dialysis outcomes and practice patterns study, DOPPS 4 N/A Recruiting Winklhofer, Franz Denise Loftiss RN, 588-7609  dloftiss@kumc.edu
End Stage Renal Disease - secondary hyperparathyroidism A Multicenter, Randomized, Open Label Study to Compare the Efficacy of Cinacalcet versus Traditional Vitamin D Therapy for Management of Secondary Hyperparathyroidism Among Subjects Undergoing Hemodialysis III Active/Not Recruiting Wetmore, James Cathy Creed RN, 588-0053
ccreed@kumc.edu
End Stage Renal Disease - secondary hyperparathyroidism Evaluation Of Cinacalcet HCl Therapy to Lower CardioVascular Events III Active/Not Recruiting Wetmore, James

Cathy Creed RN, 588-0053
ccreed@kumc.edu
Focal Segmental Glomerulosclerosis Novel therapies for resisitant focal segmental glomerulosclerosis (FSGS): A phase 2 clinical trial II Recruiting McCarthy, Ellen Pam Lanza RN, 588-8983  planza@kumc.edu

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Pulmonary & Critical Care 
Condition Title Phase Status Principal Investigator Contact Info
CF Cystic Fibrosis Foundation Annual Patient Registry IV Recruiting Steven Stites, MD snekkalapudi@kumc.edu
or 913-588-4022
COPD Long-Term oxygen treatment trial N/A Recruiting Heath Latham, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH A Randomised, Multicenter Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects with Pulmonary Arterial Hypertension III Active/Not Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH A post marketing observational study to assess respiratory tract adverse events in pulmonary arterial hypertension patients treated with Tyvaso (Treprostinil) inhalation solution   IV Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH A multicenter, double-blind, placebo controlled Phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension III Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH Long-term single-arm open-label study, to assess the safety and tolerability of ACT-293987 in patients with pulmonary arterial hypertensio III Active/Not Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH Effects of combination of bosentan and sildenafil versus sildenafil monotherapy on morbidity and mortality in symptomatic patients with pulmonary arterial hypertension – A multicenter, double-blind, randomized, placebo-controlled, parallel group, prospective, event driven Phase IV study IV Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel group, Event driven, Phase III study to assess the effects of ACT-064992 on Morbidity and Mortality in patients with Symptomatic Pulmonary Arterial Hypertension III Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH Long-term single-arm open-label extension study of the SERAPHIN study, to assess the safety and tolerability of ACT-064992 in patients with symptomatic pulmonary arterial hypertension III Active/Not Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu or 913-588-4022
PAH Registry to Prospectively Evaluate Use of Ventavis®  in Patients with Pulmonary Arterial Hypertension IV Active/Not Recruiting Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PAH A 16-Week, International, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Oral UT-15C Sustained Release Tablets in Subjects with Pulmonary Arterial Hypertension III Completed Timothy Williamson, MD snekkalapudi@kumc.edu or 913-588-4022
PAH An Open-Label Extension Trial of UT-15C SR in Subjects with Pulmonary Arterial Hypertension III Completed Timothy Williamson, MD snekkalapudi@kumc.edu
or 913-588-4022
PoPH An open label study to assess the safety and efficacy of treprostinil to facilitate liver transplantation in patients with Portopulmonary hypertension IV Recruiting Leslie Spikes, MD snekkalapudi@kumc.edu
or 913-588-4022