Ph.D., Post Graduate Institute of Medical Education & Research, Chandigarh, India, 2003
University of Kansas Medical Center, Kansas City, KS, 2003-2007.
Research in my laboratory is focused on understanding the pathogenesis of HIV-associated end stage diseases particularly cardio-pulmonary disorders. The complications associated with AIDS in the ART era are evolving away from those of an infectious nature and towards noninfectious consequences of prolonged survival. HIV-related pulmonary hypertension (HIV-PAH) is a particularly severe example and the majority of HIV-PAH occurs in individuals with a history of intravenous drug use. One of my primary research efforts is aimed at understanding mechanistically how HIV-1 and drugs of abuse contribute alone and in concert to the vascular dysfunction associated with PAH. Other focus of the lab is to unravel the interplay of macrophages, cytokines and chemokines in lung infections associated with HIV-infection and cigarette smoking.
Current research is aimed at:
elucidating the underlying molecular mechanism(s) involved in the augmentation of HIV-protein related pulmonary smooth muscle hyperplasia in the presence of illicit drugs.
explore the role of growth factors and extracellular matrix proteins.
determine the involvement of anti-proliferative bone morphogenetic protein receptor (BMPR) axis.
defining the mechanistic pathway(s) responsible for tight junction disassembly that results in augmentation of HIV- related pulmonary endothelial dysfunction.
Selected peer-reviewed publications (in chronological order):
Navneet K. Dhillon, Yongjun Sui, Raghava Potula, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Francois Villinger, David Pinson, Opendra Narayan, and Shilpa Buch. 2005. Inhibition of Pathogenic SHIV Replication in Macaques Treated With Antisense DNA of Interleukin-4. Blood. April; 105(8):3094-3099.
Navneet K. Dhillon, Sukhbir Dhillon, Yahia Chebloune, David Pinson Francois Villinger and Shilpa Buch. 2006. Therapy of SHIV Infected Macaques with Liposomes Delivering Antisense IL-4 DNA. AIDS. May 12;20(8):1125-30
Navneet K. Dhillon*,Yongjun Sui*, David Pinson, Shanping Li, Sukhbir Dhillon, Ossama Tawfik, Shannon Callen, Olga Nemon, Opendra Narayan, Shilpa Buch (*co first authors ).2007. Up-regulation of PDGF and its Receptor Expression in Simian-Human Immunodeficiency Virus-Associated Pneumonia in Macaques. AIDS. Jan 30; 21(3):307-316.
Navneet K. Dhillon, D Pinson, S Dhillon, O Tawfik, M Danley, M Davis, O Nemon, M Mayo, A Kumar, Y Tsai, A Kumar, and S Buch. 2007. Bleomycin Treatment causes Enhancement of Virus Replication in the Lungs of SHIV- infected Macaques. Am J Physiol Lung Cell Mol Physiol. May; 292(5):L1233-40.
Navneet K. Dhillon, Fuwang Peng, Richard R. Ransohoff, Shilpa Buch. 2007, PDGF Synergistically Enhances IFN-g Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV-Dementia. J. Immunology Sep 1; 179(5):2722-30.
Navneet K. Dhillon, Rachel Williams, Fuwang Peng, Yi-jou Tsai, Sukhbir Dhillon, Brandon Nicolay, Milind Gadgil and Shilpa J. Buch. 2007, Cocaine-mediated Enhancement of Virus Replication in Macrophages: Implications for HIV-Dementia.J Neurovirology. Dec; 13(6):483-95.
Sonja Bartolome, Navneet K. Dhillon, Shilpa Buch, Alfred J. Casillan, John G.Wood and Amy R. O'Brien-Ladner. 2009. Deferoxamine Mimics the Pattern of Hypoxia-related Injury at the Microvasculature. SHOCK. 31(5):481-485.
Navneet K. Dhillon*, William J. Murphy*, Michael B. Filla, Ana J. Crespo, Heath A. Latham and Amy O’Brien-Ladner (*co first authors).2009. Down modulation of IFN-g Signaling in Alveolar Macrophages Isolated from Smokers. Toxicology & Applied Pharmacology. May 15; 237(1):22-8. Epub 2009 Mar 6.
A. Baoum, Navneet K. Dhillon, S. Buch, and C. Berkland. Cationic surface modification of PLG nanoparticles offers sustained gene delivery to pulmonary epithelial cells.2009. J Pharm Sci. 2010 May;99(5):2413-22.
Navneet K. Dhillon*, Fang Li, Bing Xue, Ossama Tawfik, Susan Morgello, Shilpa Buch, Amy O’Brien Ladner (*Corresponding author). Effect of cocaine on HIV-mediated pulmonary endothelial and smooth muscle dysfunction.Am J Respir Cell Mol Biol. 2011 Jul; 45(1):40-52. Epub 2010 Aug 27. Figure selected for the journal’s cover page.
Joel Mermis, Haihua Gu, Fang Li, Ossama Tawfik, Shilpa J. Buch, Amy O’Brien-Ladner, Navneet K. Dhillon. ROS/HIF dependent up-regulation of PDGF-BB by HIV-proteins in pulmonary endothelial cells. Respir Res. 2011 Aug 5; 12(1):103.
Leslie Spikes, Pranjali Dalvi, Ossama Tawfik, Haihua Gu, Norbert F Voelkel, Paul Cheney, Amy O'Brien-Ladner, Navneet K. Dhillon. Enhanced Pulmonary Arteriopathy in SIV-Infected Macaques Exposed to Morphine. Am J Respir Crit Care Med. 2012; 185(11): 1235-1243. Related Editorialon pages:1144-6.