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The Center for Reproductive Sciences

Faculty

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Brian Petroff, DVM, PhD
Assistant Professor Internal Medicine

Research Description

Women’s cancers (i.e. breast and ovarian cancer) and infertility share a number of suspected disease pathways and risk factors.  My laboratory focuses on the prevention of these conditions through the characterization and antagonism of promising drug targets in human and animal chemoprevention trials.   Major research efforts include characterization and alleviation of the loss of fertility with age and in polluted environments, the development of animal models of women at high risk for simultaneous breast and ovarian cancer and the use of proteomic, RNA and laser capture microssection technologies to assess early markers of risk for breast and ovarian cancer.  Additionally, I direct the developmental research in the Breast Cancer Prevention Center, particularly the testing of promising chemopreventives for breast and ovarian cancer in human clinical trials.

Representative Publications

Franczak A, Nynca A, Valdez KE, Mizinga KM, Petroff BK. Effects of acute and chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin on the transition to reproductive senescence in female Sprague Dawley rats. Biol Reprod 2005; 74:125-130.

 

Petroff BK, Clark JL, Metheny T, Xue Q, Kimler BF, Fabian CJ. Optimization of estrogen receptor analysis by immunocytochemistry in random periareolar fine needle aspirates of benign breast tissue processed using thin layer preparation technology. Appl Immunohist Mol Morph 2006; in press.

 

Petroff BK, Phillips TL, Kimler BF, Fabian CJ. Detection of biomarker gene expression by real-time polymerase chain reaction using amplified ribonucleic acids from formalin-fixed random periareolar fine needle aspirates of human breast tissue. Anal Quant Cytol Histol 2006; In press.

 

Shi ZQ, Valdez KE, Ting A, Gum S, Franczak A, Petroff BK. Chronic AhR ligand exposure accelerates reproductive aging via ovarian endocrine disruption at environmentally relevant exposures. Biol Reprod 2006; In press.

Ting A, Valdez KE, Xue Q, Kimler BF, Fabian CJ, Petroff BK. A rodent model for testing of dual target chemoprevention drugs against breast and ovarian cancer. Carcinogenesis 2006; In press.

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