Faculty

Research Description

My research focuses on the role of tissue remodeling factors in the female reproductive tract.  Our major area of interest is the role of the matrix metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs) in uterine growth, development and function.  Using TIMP-1 deficient mice, we have demonstrated that absence of the TIMP-1 gene product results in alterations in uterine development and reduced reproductive lifespan.   Current studies are aimed at determining the mechanisms by which TIMP-1 regulates uterine development and growth and employ a variety of molecular, cellular and biochemical techniques.

A second project in my laboratory focuses on the role of TIMP-1 in corpus luteum physiology and function.  The corpus luteum produces progesterone which is essential for the establishment of pregnancy.  We have demonstrated that TIMP-1 deficient mice are subfertile and this subfertility is associated with reduced progesterone production and systemic levels of this steroid.  We are currently examining the mechanisms by which TIMP-1 influences corpus luteum progesterone production using both in vivo and in vitro methodologies.

A third research interest of my laboratory involves the study of the female disease endometriosis.   Endometriosis occurs in as many as 10% of all women of reproductive age and is defined as the presence of endometrial tissue in ectopic locations.   We are currently examining the role of cytokines, particularly tumor necrosis factor alpha, in the pathophysiology of the disease.  Understanding the mechanisms by which this inflammatory mediator may contribute to the development of endometriosis will lead to the development of novel treatments for the disease which would offer benefits over current therapies.