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The Center for Reproductive Sciences

Faculty

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Gaurav Chaturvedi , PhD
Research Assistant Professor Molecular & Integrative Physiology

Research Description

My research is primarily directed at understanding the mechanisms by which human embryonic stem cells maintain pluripotency and to find out ways to prolong the pluripotent state of hESCs in vitro. My studies indicate that noggin, a BMP4 antagonist, is effective in preventing spontaneous differentiation in hESC culture on Matrigel for up to two weeks. The current research is focused at finding out the involvement of various signal transduction pathways involved in maintenance of pluripotency by noggin. Another recent project is a xenobiotic stimulation of human embryonic stem cells to differentiatethem in to kidney lineage by using embryonic kidney conditioned media. I am also involved in finding out the nature of heteromeric protein complex formed by Egr, Nab and CBP on the LH beta promoter in gonadotrophs.

Representative Publications

  • GS Gupta, G Chaturvedi and A Joshi. Sex dependent immune responses by allogenic LDH isozymes. Molecular and Cellular Biochemistry , 158 : 115-119, 1996.

  • Gupta GS, Chaturvedi G . Regulation of immune functions by sperm-specific LDH and its differences with somatic isozyme in primary and secondary lymphocyte cultures. Am. J. Reprod Immunol . 2000 Sep;44(3):160-9.

  • G Chaturvedi, R Tewari, Mrigank, N Agnihotri, RA Vishwakarma and NK Ganguly. Structural evaluation of a peptide from a 20kDa adhesin which inhibits Helicobacter pylori adherence to HEp-2 cells in vitro. Mol Cell Biochem 2001 Dec;228(1-2):83-9

  • A. Farooq, G Chaturvedi , S. Mujtaba, O. Plotnikova, L. Zeng,C. Dhalluin, R. Ashton and MM Zhou. Solution Structure of ERK2 Binding Domain of MAPK phosphatase MKP-3: Structural insights into MKP-3 Activation by ERK2. Molecular Cell . 2001 Feb;7(2): 387-399

  • Chaturvedi G., Farooq A., Zeng L., and Zhou M.-M 1H,13C and 15N resonance assignments of the catalytic domain of human MAPK phaphatase, PAC-1. J. Biomol. NMR. 2002,25:79-80

  • Farooq A., Plotnikova O., Chaturvedi G.,, Yan S., Zeng L., Zhang Q., and Zhou M.-M Solution Structure of the catalytic domain of MAPK phosphatase PAC-1: Insights in to substrate –induced enzymatic activation. Structure (Camb) 2002, 11: 155-164

  • G Chaturvedi, K.F. Roby and P.F. Terranova. Inhibition of src tyrosine kinase enhances ovarian thecal cell androgen production. (Abstract) Biology of Reproduction, 2003, 68 ( Suppl 1):232

  • G Chaturvedi, Arai K., Limback D.,K.F. Roby and P.F. Terranova. Regulation of cyp17 Expression in Theca-enriched Mouse Ovarian Cells by Src Tyrosine Kinase. Endocrine. 2004,25(2): 147-154

  • G Chaturvedi, Arai K., Limback D.,K.F. Roby and P.F. Terranova. Mechanism of Cyp17 Expressionand Androgen biosynthesis in mouse; involvement of ERK pathway. (Comunicated to Journal of Endocrinology )

  • G Chaturvedi, P Simone, MJ Soares and MW Wolfe. Noggin helps maintain pluripotency in human embryonic stem cells cultured on Matrigel. (Manuscript under preparation).

  • Gerald B. Call, Gaurav Chaturvedi and Michael W. Wolfe. Gonadotropin-releasing hormone activation of the human luteinizing hormone beta-subunit promoter in LbetaT2 cells: requirement for protein kinase C, extracellular signal regulated kinase and Egr response elements. (Manuscript under Preparation)

  • Michael W. Wolfe, Sara Turk, Emily McDonald and Gaurav Chaturvedi. GnRH and PACAP induce Egr1 expression in gonadotropes, but differentially effect nuclear translocation. (Manuscript under Preparation)

 

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